SOM Biotech’s pipeline mainly contains programs focused on orphan diseases with high unmet medical needs  

 All programs are obtained through the proprietary AI-based technology.

Product

Therapeutic area

Indication

Discovery

Preclinical

Phase I

Phase II

Phase III

Commercial Rights

SOM3355

Neurology

Chorea in Huntington’s disease

 
75%

SOM0226

Neurology

TTR Amyloidosis

 
70%

SOM1311

Neurology

Phenylketonuria

 
67%

SOM0061

Infectious Disease

COVID-19

 
67%

SOM3366

Neurology

 Tardive Dyskinesia

 
53%

SOM0777

Neurology/Oncology

Glioblastoma

 
45%

SOM0034

Neurology

Confidential

 
35%

SOM0208

Neurology

Confidential

 
35%

SOM0044

Neurology

Confidential

 
30%

SOM0045

Neurology

Confidential

 
30%

SOM3355

Chorea movements associated with Huntington’s disease

SOM3355 is an oral VMAT2 inhibitor (vesicular monoamine transporter 2) for the symptomatic treatment of chorea movements associated with Huntington’s disease (HD). SOM3355 has successfully completed Phase 2a trials in HD and shown a favourable safety profile with no depression effects. The program received positive results of Pre-IND with US Food and Drug Administration (FDA) and Scientific Advice with European Medicines Agency. SOM3355 has also been granted  Orphan Drug Designation by the US FDA. A Phase 2b dose range trial for the drug will be initiated in the EU in 2022. You can find more information about clinical trials for SOM3355 here NCT03575676.

Huntington’s disease is an inherited disease that causes the progressive breakdown (degeneration) of nerve cells in the brain. Huntington’s disease has a broad impact on a person’s functional abilities and usually results in movement, thinking (cognitive) and psychiatric disorders.

SOM0226

TTR amyloidosis 

SOM0226 is a small molecule transthyretin (TTR) stabilizer for the treatment of TTR amyloidosis. It is active on different TTR mutations and has shown clinical efficacy in stabilizing plasma TTR in healthy volunteers and patients with Familial Amyloid Polyneuropathy (FAP) after oral administration. SOM0226 was outlicensed to Corino Therapeutics  based in the US and is currently in development for different forms of TTR amyloidosis

TTR amyloidosis occurs when the protein Transthyretin (a protein that is mainly made in the liver), “misfolds” or binds together to form fibrous clumps. Depending on the specific type of TTR amyloidosis, the amyloid is deposited into various organs and/or nerves, which can lead to permanent damage and organ malfunction, including heart failure.

SOM1311

Phenylketonuria

SOM1311 is a small molecule pharmacological chaperone of Phenylalanine Hydroxylase for the treatment of Phenylketonuria. The response rate of the drug is higher compared with the current standard of care. Clinical Phase 2a trial initiation expected at the beginning of 2023.

Phenylketonuria (PKU) is characterized by a birth defect that causes the amino acid, phenylamine to build up in the body. Untreated, PKU can lead to intellectual disability, seizures, behavioral problems, and mental disorders.

SOM3366

Tardive Dyskinesia

SOM3366 is an oral VMAT2 inhibitor (vesicular monoamine transporter 2) for the symptomatic treatment of Tardive Dyskinesia (TD). SOM3366 is currently finishing preclinical development in TD, with Phase 1 clinical trial initiation expected in 2022.

Tardive Dyskinesia is an involuntary neurological movement disorder caused by the use of neuroleptic drugs that are prescribed to treat certain psychiatric or gastrointestinal conditions.

SOM0061

COVID-19

SOM0061 program includes three drug candidates for the treatment of COVID-19.

SOM Biotech has applied its intelligence-based technology (SOMAIPRO) to identify inhibitors of the 3CL proteases of SARS-CoV-2, SARS-CoV and MERS-CoV viruses as potential candidates to treat Coronavirus Disease 2019 (COVID-19). Identified drug candidates were validated in vitro in collaboration with the Department of Pharmacy and Pharmaceutical Sciences led by Professor Dong-Hae Shin from Ewha Womans University in South Korea. One of the repurposed drug candidates is Phase 2a ready.

COVID-19 is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Common symptoms include fever, cough, and shortness of breath. Other symptoms may include fatigue, muscle pain, diarrhea, sore throat, loss of smell, and abdominal pain.

SOM0777

Glioblastoma

SOM0777 is a small molecule for the treatment, Glioblastoma. SOM0777 was outlicensed to U-Cell Therapeutics, based in Singapore, which is developing safe ways of administration and delivery in the tumour. When these new formulations are developed and ready for clinical testing, U-Cell Therapeutics will perform the clinical proof-of-concept study and the rest of clinical development.

Glioblastoma is an aggressive cancer that occurs in the brain and spinal cord. Initially, signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality changes, nausea, and symptoms similar to those of a stroke. Worsening of symptoms is often rapid, and may progress to unconsciousness. The cause of most cases is unclear. Uncommon risk factors include genetic disorders, such as neurofibromatosis and Li–Fraumeni syndrome, and previous radiation therapy. Glioblastomas represent 15% of brain tumors.

To learn more about the pipeline of SOM Biotech and 20 more Orphan indications that we are working on, you can contact us.